How to Formulate Stable Multi-API ODFs — Challenges and Engineering Solutions

Going beyond simple ODFs: How to design and produce advanced multi-ingredient films.

Challenges in Multi-Ingredient Film Formulation

Developing ODFs with two or more active ingredients (APIs) introduces formulation complexity beyond basic mono-layer films. Common issues include:

• Incompatibility between APIs or excipients
• Migration or separation during drying
• Weak bonding between layers in dual-action films
• Delamination due to drying or film tension inconsistency

Engineering Solutions from the Ground Up

At HUANGHAI, we combine formulation expertise with precision equipment design to solve these problems systematically:

• Real-world drying: Our drying tunnel uses a natural hot-air gradient — hotter near the inlet, cooler at the exit — to enable progressive solvent removal and reduce layer separation.
• Multi-layer coating design: Optional multi-head coaters and tension control ensure consistent thickness and inter-layer bonding.
• Pilot testing: Validate formulations using the MJ150-L before scaling to industrial lines.
• Joint R&D: Our team works with you on excipient screening and drying temperature calibration to match product and process goals.

Recommended Equipment

Explore ODF coating systems compatible with multi-API production:

• MJ150-L Pilot Coater
• MJ150 Industrial Coater
• MJF180 Cutter & Packer