Dissolution Testing Instruments

Dissolution Testing Instruments for Tablets and Capsules

Dissolution testing is a critical step in pharmaceutical quality control and R&D. It ensures consistent drug release and bioavailability across batches. Our RCZ series Dissolution Testers are engineered to meet the latest USP, EP, and ChP standards.

Key Features of Our Dissolution Equipment

  • High-precision temperature and RPM control
  • Customizable baskets, paddles, and sampling systems
  • Touchscreen interface with real-time data export
  • Models available for 1, 6, 8, and 12 vessels

Applications

  • Tablet and capsule quality testing
  • Generic drug bioequivalence studies
  • Research and development in pharma labs

Explore the full lineup below to find the right solution for your lab. For quotation or technical support, contact our team.

How to choose a dissolution tester

Huanghai Pharmaceutical Instruments (Shanghai, since 1978) makes dissolution testers from a single-station unit to 12-vessel systems with automated sampling. Every RCZ model runs USP Apparatus 1 (basket) and Apparatus 2 (paddle) at 10–300 RPM and follows USP <711>, ChP 0931 and Ph. Eur. 2.9.3. The main choice is the number of vessels you need per run and whether you need user management and audit trail for regulated QC.

Model comparison

Model Vessels Apparatus Data and access control Typical use
RCZ-1B 1 USP 1 / 2, 10–300 RPM RS232 printer, USB TXT export Method development, teaching, small labs
RCZ-6N 6 USP 1 / 2, 10–300 RPM 3-level users, audit trail, USB; 2 × 150 ml replenishment vessels Routine QC release testing
RCZ-8N 8 USP 1 / 2, 10–300 RPM 3-level users, audit trail, USB, scheduled heating QC with 6 test vessels + 2 for blanks or standards
RCZ-8A 8 USP 1 / 2, separate stirring, auto tablet drop 3-level users, audit trail, USB Automated QC; pairs with RCZ-QY8 sampling
RCZ-12A 12 USP 1 / 2, separate stirring, auto tablet drop 3-level users, audit trail, USB High-throughput QC; pairs with RCZ-QY12 sampling
RCZ-QY8 / QY12 8 / 12 Automated timed sampling Inherits tester data features Unattended multi-point dissolution profiles

How to choose

  • Up to 6 vessels: one USP <711> stage tests 6 units, so a 6-vessel tester (RCZ-6N) runs a full stage in one run.
  • Need blanks, standards or two products side by side: choose 8 vessels (RCZ-8N or RCZ-8A); for more than three active products in QC, consider 12 vessels (RCZ-12A).
  • Regulated QC with data-integrity requirements: choose a model with 3-level user management and audit trail (RCZ-6N, 8N, 8A, 12A). These are designed with features that support a 21 CFR Part 11 workflow; RCZ-1B is for non-GxP work.
  • Long or frequent multi-point profiles: add automated sampling (RCZ-QY8 with RCZ-8A, RCZ-QY12 with RCZ-12A).
  • Light-sensitive APIs: RCZ-6N, 8N, 8A and 12A can be configured with amber glass vessels of the same 1,000 ml size.
  • Degassed media: prepare purified water with the HTQ-1A vacuum degasser before the run.

Pharmacopoeia and compliance

USP <711> Apparatus 1 (basket) and Apparatus 2 (paddle), ChP 0931, Ph. Eur. 2.9.3 (BP Appendix XII B1). The basket and paddle apparatus is harmonised between USP, Ph. Eur. and JP. IQ/OQ documentation templates are supplied with each instrument.

Frequently asked questions

What is the difference between USP Apparatus 1 and Apparatus 2?
Apparatus 1 holds the dosage form in a rotating basket and is common for capsules and floating products; Apparatus 2 uses a rotating paddle and is the most common method for tablets. All Huanghai RCZ dissolution testers support both.

How many vessels does a dissolution tester need?
USP <711> tests 6 units per stage, so 6 vessels is the practical minimum for QC release. 8 vessels leave room for blanks or a reference, and 12 vessels suit labs testing several products every day.

Which models have audit trail and user management?
RCZ-6N, RCZ-8N, RCZ-8A and RCZ-12A have 3-level user management (Admin / Power User / User), an audit trail and USB data export. RCZ-1B has printer and USB output without user login.

Can the sampling be automated?
Yes. RCZ-QY8 (with RCZ-8A) and RCZ-QY12 (with RCZ-12A) withdraw samples automatically at preset time points.

What speed range do Huanghai dissolution testers cover?
All RCZ models run 10–300 RPM, which covers the usual 50 RPM (paddle) and 100 RPM (basket) method settings.

Related guides: Dissolution Apparatus 1 vs 2 buying guide · Why degas media before dissolution testing · HTQ-1A vacuum degasser

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