Laser Drilling Solution for Osmotic Tablets

Laser Drilling Solution for Osmotic Tablets

End-to-end laser drilling for osmotic controlled-release tablets — pairing the Olando K3-2 system with vision QC, dust extraction, and GMP/MES integration.

Overview

Our laser drilling solution enables precise apertures (typ. sub-millimeter) for osmotic tablets to achieve stable release profiles. The solution can run stand-alone or be integrated inline, and supports GMP cleanroom operation with electronic record features and MES connectivity.

Core Modules

  • Olando K3-2 Laser Drilling System (configurable for single/dual apertures).
  • Vision inspection for aperture presence/diameter/positioning; reject handling.
  • Dust extraction & tablet handling designed for cleanroom environments.
  • Batch management with optional MES/ERP interface and e-records support.
  • Validation documentation and operator/maintenance training services.

Client Case Studies

Client Case 1 — Shanghai Modern Pharmaceutical Co., Ltd.

  • Company: Shanghai Modern Pharmaceutical Co., Ltd.
  • Type: Publicly listed pharmaceutical enterprise
  • Headquarters: Shanghai, China
  • Specialty: Controlled-release oral solid dosage manufacturing

Cooperation History

Shanghai Modern Pharmaceutical has been a key user of our laser drilling technology for nearly 20 years. Starting from the first-generation Olando systems, they have continuously upgraded with our latest models, including the K3 series. To date, they have purchased and deployed a total of 12 Olando laser drilling machines in their production facilities.

Product Application

  • Nifedipine Controlled-Release Tablets (CR) — requiring precise laser-drilled apertures to control osmotic release over an extended period, ensuring consistent therapeutic effects.

GMP Compliance & Performance

  • All equipment is operated in full GMP-compliant cleanroom environments.
  • Systems have demonstrated high precision, stable throughput, and strong reliability under daily industrial-scale production.
  • Long-term cooperation and repeated purchases underscore proven performance and after-sales support quality.

Workshop and product photos:

Shanghai Modern Pharmaceutical laser drilling line - photo 1
Olando system in GMP cleanroom - photo 2
Laser-drilled tablets (close-up) - photo 3
Production environment and equipment - photo 4

Client Case 2 — Shanghai Xinyi Pharmaceutical Co., Ltd.

  • Company: Shanghai Xinyi Pharmaceutical Co., Ltd.
  • Established: 1943
  • Core Focus: Prescription drugs and sustained-release dosage forms
  • Ownership: Subsidiary of Shanghai Pharmaceutical Holding Co., Ltd. (SSE-listed)

Project Summary

In 2023, Xinyi Pharmaceutical purchased three units of our Olando K3-2 Laser Drilling System for their advanced formulation line. These machines are specifically used in the production of Doxazosin Mesylate Controlled-Release Tablets, a medication commonly used to treat hypertension and benign prostatic hyperplasia (BPH).

Application Focus

  • Product: Doxazosin Mesylate Controlled-Release Tablets
  • Formulation Requirement: Laser-drilled membrane enables controlled drug release and stable pharmacokinetics
  • Precision Need: Uniform aperture size and placement for accurate release profiles

Performance & GMP Compliance

  • Equipment is installed within fully GMP-certified workshops, integrated with the client’s MES system.
  • Client reported smooth integration, reliable aperture quality, and consistent output across batches.
  • We also provided remote support and ongoing maintenance training.

Facility and tablet photos:

Xinyi Pharmaceutical — Olando K3-2 installation - photo 1
Laser-drilled tablets close-up - photo 2

Planning an osmotic CR tablet line or retrofit?

 

Contact us