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RYJ-12B Transdermal Diffusion Tester – In-Vitro Skin Absorption Testing Instrument
Regular price From $3,351.00 USDRegular priceUnit price perDistributor & agent pricing available on request. Equipping a full QC lab? Ask about multi-unit bundle pricing.
How to choose a transdermal diffusion tester
A transdermal diffusion tester measures how an active ingredient is released from a patch, cream or gel and how it permeates a membrane: the in-vitro release and permeation tests used in topical and transdermal product development and QC. The RYJ-12B from Huanghai Pharmaceutical Instruments (Shanghai, since 1978) runs 12 wet-type vertical diffusion cells (Franz-type) in parallel, the apparatus described in USP <1724>.
Model comparison
| Model | Cells | Cell type | Temperature | Best for |
|---|---|---|---|---|
| RYJ-12B | 12 | Wet-type vertical (Franz-type) | Room temperature to 45 °C; 50 °C or higher on request | Parallel release and permeation runs on patches, creams and gels |
How to choose
- Replicates: release-rate comparisons usually use 6 cells per product, so 12 cells let you run test and reference products in the same run.
- Temperature: skin-surface studies are commonly run at about 32 °C. The RYJ-12B covers room temperature to 45 °C, and the heating can be modified to reach 50 °C or more if your protocol needs it.
- Dry-type horizontal cells as well: ask about the TPY-2 dual-method diffusion tester (12 wet vertical + 6 dry horizontal cells).
- Records: test records can be exported over USB.
Pharmacopoeia and compliance
Vertical diffusion cell (Franz-type) methods per USP <1724>, together with USP <724>; ChP patch-release methods. Ph. Eur. 2.9.4 uses a dissolution-type apparatus rather than Franz cells.
Frequently asked questions
What is a Franz diffusion cell?
A vertical cell in which the membrane sits between a donor chamber above and a receptor chamber below. The receptor medium is stirred at a controlled temperature and sampled over time to measure release or permeation.
Which standards apply?
USP <1724> vertical diffusion cell methods for semisolid products and USP <724>, plus ChP patch-release methods.
How many cells does the RYJ-12B have?
12 wet-type vertical diffusion cells, run in parallel.
What temperature range does it cover?
Room temperature to 45 °C as standard. The heating module can be modified to reach 50 °C or more on request.
What stirring speed and temperature control do the Franz diffusion cells offer?
The Huanghai RYJ-12B gives you steady receptor conditions across all 12 cells in one run: stirring from 100 to 800 RPM and temperature control from room temperature to 45 °C within ±0.3 °C. When a protocol needs more heat, the heating module can be modified to reach 50 °C or higher.
What receptor volume and diffusion area does each cell have?
Each cell of the Huanghai RYJ-12B is a modified vertical Franz cell with an 8 ml receptor and a diffusion area of about 2.2 cm². Because the receptor is small, draw small aliquots and replace them with fresh, pre-warmed medium so the volume stays at the mark; runs of up to 9,999 minutes cover multi-day release profiles.
What equipment do I need to set up a transdermal patch development lab?
You need a way to make small patch batches and a way to measure release or permeation, and Huanghai supplies both: the MJ150-RD coating line for coating, drying and rewinding the patch layer, and the RYJ-12B diffusion tester for release and permeation studies. The TDDS complete solution page lays out the full set-up.
Related guides: RYJ-12B Franz cell diffusion tester · Franz cell setup · TDDS complete solution