Pharmaceutical Laser Tablet Drilling Solutions

Laser Tablet Drilling Solutions

Osmotic-release tablets rely on a precisely drilled micro-hole to control drug release rate. Our Olando K3-2 Laser Drilling System is built for this high-precision process; its design builds on Academician Hou Huimin's foundational laser-drilling patent CN2642449Y.

Key Features

  • High-precision laser micro-hole drilling for controlled-release tablets
  • Design based on Academician Hou Huimin's patent CN2642449Y (2003)

Applications

  • Osmotic pump (OROS-type) controlled-release tablet manufacturing
  • Micro-hole drilling for other precision-release dosage forms

Explore the full lineup below to find the right solution for your lab. For quotation or technical support, contact our team.

How to choose a laser drilling system for osmotic tablets

Osmotic-pump controlled-release tablets release the drug through a laser-drilled orifice in the coating, so hole position and depth control the release. The Olando K3-2 from Huanghai Pharmaceutical Instruments drills blind or through holes at up to 120,000 tablets per hour, with ±0.1 mm accuracy and ±0.05 mm hole-depth consistency, on round and bilayer tablets of 6–20 mm diameter. Its design builds on Academician Hou Huimin's foundational osmotic-tablet laser-drilling patent CN2642449Y.

Model comparison

Module Function
Olando K3-2 drilling unit Single- or dual-aperture laser drilling, up to 120,000 tablets per hour
Vision inspection Dual-station closed-loop inspection with real-time rejection
Dust extraction Dust extraction and cleanroom-compatible handling
Batch management Batch records with MES/ERP interface; Siemens PLC and electrical components
Validation and training Validation documentation and operator training

How to choose

  • Tablet geometry: round and bilayer tablets of 6–20 mm diameter.
  • Hole type: blind holes or through holes, with ±0.1 mm accuracy and ±0.05 mm hole-depth consistency.
  • Output: up to 120,000 tablets per hour per system; for larger volumes, plan several identical lines.
  • Quality control: dual-station closed-loop vision inspection rejects defective tablets in real time.
  • Data integrity: batch management with MES/ERP interface, designed to support 21 CFR Part 11 compliance.

Pharmacopoeia and compliance

Designed for cGMP production and to support 21 CFR Part 11 compliance (audit trail, electronic records, access control); final compliance is established within the user's own validated system. Validation documentation and operator training are part of the solution.

Frequently asked questions

Why do osmotic tablets need laser drilling?
An osmotic-pump tablet releases the drug through a small orifice in its coating. Laser drilling makes that orifice with consistent position and depth, which keeps the release profile consistent from tablet to tablet.

What output does the Olando K3-2 reach?
Up to 120,000 tablets per hour.

Which tablets can it drill?
Round and bilayer tablets of 6–20 mm diameter, with blind or through holes.

Who uses the Olando K3-2?
Shanghai Modern Pharmaceutical runs 12 units for nifedipine controlled-release tablets, and Shanghai Xinyi Pharmaceutical installed 3 units in 2023 for doxazosin mesylate controlled-release tablets.

Related guides: Laser drilling solution for osmotic tablets · Why osmotic tablets need laser drilling · Olando K3-2 system guide

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