Solutions -End-to-End Manufacturing Solutions for ODF, Patches, and Tablets

Tailored solutions for efficient production of ODF (Oral Dissolving Films) and solvent-based transdermal patches. Whether you are looking for small-scale research, pilot-scale production, or large-scale manufacturing, we have the right solution for your business needs.

How It Works: Unlock Your Production Potential

We kindly invite you to share your production goals so that we can better understand your specific pharmaceutical formulas and production requirements. To assist us in tailoring the best solution for you, please provide:

• Factory Layout: A floor plan to help us optimize equipment placement and streamline workflow.
• Product Specifications: Drawings or dimensions of your product or packaging to ensure precise equipment design.
• Production Goals: Your desired capacity and technical requirements to guide our recommendations.

Formula Testing

• We utilize industry-standard instruments and a variety of excipients to simulate real production conditions.
• Your formulations are tested on our pharmaceutical machinery to evaluate performance, efficiency, and compatibility with our equipment.
• All testing data is securely recorded for future analysis, ensuring traceability and continuous improvement.

Formula Optimization

• Enhance the stability and consistency of your formulations.
• Improve the quality and yield of your final product.
• Customize the process to meet regulatory standards and specific production goals.

Manufacturing Solutions by Category

ODF (Oral Disintegrating Films)

End-to-end solutions for oral disintegrating films, from emulsification to packaging, based on your finalized formula, production capacity, and product specs:

• Emulsification
• Film Production
• Film Packaging
• Cartoning

Solvent-Based Transdermal Patches

We design streamlined production processes addressing challenges in drug distribution, coating, and drying:

• Uniform coating
• Adhesive layer compatibility
• Drying systems
• Secure packaging

Sustained-Release Tablets with Laser Drilling

Laser drilling and inspection systems for sustained-release tablets:

• Micropore drilling for controlled drug release
• Real-time monitoring and adjustment
• Automated inspection systems

Plant Layout & Facility Engineering

Factory Layout

• Optimized space utilization
• Workflow streamlining
• Compliance with GMP and international standards

Purification System

• HEPA filters and airlocks
• Environmental monitoring
• Customized for your product and facility

Water Treatment System

• PURIFIED Water: RO & DI tech
• WFI generation
• Optimized distribution systems

Construction Execution

• Accurate buildout supervision
• Timeline & quality control
• Validation support

Installation, Commissioning & Training

Equipment Installation

• On-site supervision & safety checks
• Integration testing

Equipment Commissioning

• Performance verification & calibration
• Trial batch validation

Staff Training

• Hands-on operator training
• Maintenance education
• Custom manuals provided

After-Sales Support

• Remote assistance & technical troubleshooting
• Warranty service with free parts replacement
• Periodic maintenance plans
• Training updates for new features
• Spare parts inventory with fast shipping
• Continued process optimization consultation

Ready to Transform Your Production Line?

Contact us today to learn how we can help you build a more efficient and compliant manufacturing system. 

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Frequently Asked Questions

Q: What is the difference between an ODF film and a transdermal patch?

A: Oral Dissolving Films (ODF) are placed on or under the tongue and dissolve within seconds to minutes, delivering APIs directly through the oral mucosa or via swallowing. Transdermal patches adhere to the skin and deliver APIs through the dermal layers into systemic circulation over hours to days. Despite different delivery routes, both are manufactured using similar solvent-cast film coating processes. Huanghai's MJ150 ODF machine supports both applications on a single platform with approximately 2 working days of changeover time.

Q: What production output can I expect from a Huanghai ODF machine?

A: The MJ150 produces 20,000 films/hour at commercial scale. The MJ150-L targets R&D and pilot production at 8,000–10,000 films/hour. For fully integrated lines, pair either machine with the MJF180 automatic cutting and packaging system (11,900 films/hr) or the more affordable EZ320 (9,000 films/hr). A complete MJ150 + MJF180 line can produce over 150 million finished pouches annually on a single-shift basis. Contact us for pricing and configuration details.

Q: What drying technology does Huanghai use for ODF production?

A: Huanghai uses patented gradient hot-air drying (Patent CN201668734U), which applies a smooth progressive temperature drop rather than stepwise oven zones used by competitors. This results in more uniform film thickness, reduced edge curl, and better API distribution across the film web. An optional far-infrared heating module adds 20–30% drying efficiency for solvent-based formulations. This patented drying system is one of the key technical advantages that justifies Huanghai's position as the preferred ODF equipment supplier to Sinopharm, Shanghai Pharma, and Fosun Pharma.

Q: What are the GMP requirements for ODF production equipment?

A: ODF manufacturing equipment must comply with cGMP (21 CFR Parts 210/211) for US market products, and equivalent standards (EU GMP Annex 1, ChGMP) for other markets. Key requirements: material contact surfaces must be 316L stainless steel or equivalent; CIP/SIP capability or documented cleaning validation; data integrity controls meeting ALCOA+ principles (audit trails, access control). Huanghai ODF machines meet these standards—all product contact surfaces use pharmaceutical-grade materials, and the control system includes operator access logs and parameter change records. Request our GMP compliance documentation.

Q: Can Huanghai machines produce stripe-coated or multi-formula ODF films?

A: Yes. Huanghai holds a patent for multi-formula stripe coating (Patent CN117323228A), enabling two different API formulations to be applied side-by-side in a single coating pass. This eliminates the need for multiple coating/drying cycles when producing combination-drug ODF products. Competitors require manual multi-layer coating with drying intervals between each formula. This capability is particularly valuable for fixed-dose combination products (e.g., dual-API ODFs for cardiovascular or CNS indications) where coating efficiency directly impacts production economics.