Complete ODF Film Manufacturing Solution
Complete ODF Film Manufacturing Solution
HUANGHAI delivers a complete, modular solution for Oral Dissolvable Film (ODF) manufacturing — covering everything from precise liquid preparation to high-precision coating, and automated cutting & packaging. Built to meet GMP standards, our systems scale from pilot to commercial production.
1. ODF Liquid Preparation System
Why It Matters
Consistent film quality begins with properly prepared liquids. Inadequate dispersion, poor mixing, or uncontrolled temperature can compromise the entire batch — affecting film uniformity, API distribution, and regulatory compliance.
Application Scenarios
- Pediatric oral films with suspended APIs
- Polymer matrix mixing for transdermal patches
- Ethanol-water solubilization for poorly soluble drugs
- Multi-batch formulation for CRO/CDMO pilot trials
Optional Modules
- Jacketed stainless steel tanks with CIP/SIP capabilities
- Digital PID controllers for temperature and shear rate
- Inline filtration & recirculation loops
- Real-time volume, level, and flow sensors
Technical Overview
- Volume: 30–500L (customizable)
- Control System: PLC + Touchscreen HMI
- Cleaning: Optional CIP/SIP
- Precision: Temp ±0.5°C, Mixing uniformity ±2%
- Material: 316L stainless steel (GMP-compliant)
2. Precision Coating System (ODF & Transdermal Patches)
Why It Matters
Coating thickness and uniformity are critical for dosage accuracy and film functionality. HUANGHAI’s MJ150 and MJ150‑L provide robust control over coating speed, film thickness, and drying curve — suitable for both pharma-grade ODFs and transdermal patches.
Application Scenarios
- Bilayer or dual-API oral films
- Nicotine or lidocaine patch applications
- Zinc, probiotic, or melatonin supplement films
- Flavored pediatric dissolvable film formulations
Optional Modules
- Online thickness measurement scanner
- Dual-component coating heads
- Inert gas drying tunnels
- HEPA-filtered hot air drying zones
- Auto tension control + film shortage alert
Technical Overview
MJ150 – Commercial Coating Line
- Coating Width: 130 mm
- Film Thickness: 0.1–2 mm
- Speed: 0.2–5 m/min
- Drying Tunnel Length: 6 m
- Temperature Range: up to 120°C
- Power: 12 kW
- Machine Size: 9500 × 1400 × 2150 mm
MJ150-L – Pilot Coating Line
- Coating Width: 130 mm
- Film Thickness: 0.1–2 mm
- Speed: 0.2–3 m/min
- Drying Tunnel Length: 2.5 m
- Temperature Range: up to 120°C
- Power: 15 kW
- Machine Size: 2200 × 1400 × 2150 mm
Related Equipment
3. Film Slitting & Packaging Automation
Why It Matters
HUANGHAI’s MJ180 Series allows you to scale from pilot to mass production with flexible sealing technologies.
- Standard Efficiency (Gen 1): Utilizes Rotary Heat Sealing Rollers for reliable, continuous bagging.
- High-Speed Precision (Gen 2): Upgraded with On-Demand Heat Sealing technology. This intelligent system synchronizes sealing action with film cutting, allowing for faster throughput while minimizing thermal stress on sensitive ingredients.
Application Scenarios
- Unit-dose pouch packaging
- Multi-strip format for combo therapies
- Export-quality packaging for global markets
- High-throughput production of large SKU sets
Optional Modules
- Defective film auto-rejection
- Batch number printer + barcode
- Vision inspection + audit trail logging
Technical Overview
- Speed: 0.5–3 m/min
- Cutting Length: 13–35 mm
- Precision: ±0.1 mm
- Sealing Temp: up to 180°C
- Power: 10 kW
- Machine Size: 5200 × 1450 × 2000 mm
- Control System: Touchscreen HMI + Audit Logs
- Compliance: GMP + FDA 21 CFR Part 11
Watch the MJ180 in Action
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Frequently Asked Questions
What is the difference between an ODF film and a transdermal patch?
Oral dissolving films (ODF) dissolve on or under the tongue within seconds to minutes; transdermal patches stick to the skin and release the API over hours to days. Both are made by solvent-cast film coating, and the MJ Pro coating platform can be built for either — the application is set before the machine is manufactured.
What output can I expect from Huanghai ODF machines?
MJ150-RD about 1,200 films per hour for formulation screening; MJ150-Lab 8,000–10,000 films per hour for pilot and clinical batches; MJ150 about 30,000 films per hour (Gen I) for commercial production. For packaging, the MJ180 cuts and packs about 11,900 films per hour (Gen I); the EZ320 (about 9,000 films per hour) is for food-grade films only.
What drying technology is used?
The MJ150 production line uses a hot-air parallel-flow drying tunnel based on Academician Hou Huimin's patent CN201668734U. The MJ150-RD and MJ150-Lab use oven drying.
Can Huanghai machines coat multi-formula (striped) films?
Yes. Huanghai's patent CN117323228A covers stripe coating that applies two formulations side by side in one pass, useful for fixed-dose combination films.