Next Generation of ODF Solutions
Next Generation of ODF Solutions
Beyond Equipment — Full-Spectrum Support from Formula to Film
Developing high-performance oral dissolvable films (ODFs) — especially multi-ingredient, pediatric, or dual-release formats — requires more than just coating machinery. At HUANGHAI, we combine engineering with formulation R&D to help you go from lab concept to GMP-scale production.
Limitations in Traditional ODF Production
- Multi-API complexity: Difficult to ensure even distribution or avoid chemical interactions between layers.
- Layer-by-layer coating: Requires full drying between passes, risking delamination or poor adhesion.
- No formulation support: Most suppliers do not assist in film matrix design or excipient optimization.
HUANGHAI's Integrated Solution: From R&D to Scale-Up
- Formulation Co-Development: Collaborate with our R&D team to select excipients, optimize film-forming properties, and validate process parameters.
- Multi-Layer Coating Capabilities: Support for dual-layer or sequential API coating with precise thickness and bonding control.
- Pilot-to-Production Scaling: Pilot systems with industrial logic, enabling seamless tech transfer to full GMP lines.
- Stability-Oriented Drying Design: Control humidity and drying profiles to protect sensitive actives and preserve film integrity.
HUANGHAI vs. Traditional ODF Solutions
The table below summarizes how our approach differs from standard ODF equipment manufacturers:
| Aspect | Traditional Equipment | HUANGHAI Solution |
|---|---|---|
| Scope of Service | Equipment only | Equipment + Formulation + Scale-Up |
| Multi-API Handling | Basic layering by client | Integrated design with bonding optimization |
| Formulation Involvement | Not included | Available via R&D collaboration |
| Drying Control | Fixed zones | Custom profiles + humidity monitoring |
| Pilot Testing | Not supported | Full-featured pilot system |
| Tech Transfer | Client-managed | Assisted with industrial parameters |
| Best Fit Use Cases | Simple OTC ODFs | Complex, pediatric, dual-release formats |
Applications & Collaboration Models
Whether you’re developing pediatric film products, oral strips with complex APIs, or regulatory-compliant nutraceuticals, HUANGHAI can support your journey — from formulation refinement to commercial launch.
Explore Our ODF Equipment
We offer modular equipment systems designed for both pilot trials and high-volume production. Learn more about our key products below:
MJ180 ODF Film Cutting & Packaging Machine
Precision slitting with On-Demand Heat Sealing technology (Gen 2) for high-speed, synchronized pouch packaging.
View ProductMJ150 Solvent-Based ODF & Transdermal Coating Machine
High-volume coating system with precise control over thickness, drying, and speed.
View ProductMJ150-L ODF Pilot Coating Machine
Optimized for R&D trials and formulation testing with full industrial logic.
View ProductFrequently Asked Questions
What is the difference between an ODF film and a transdermal patch?
Oral dissolving films (ODF) dissolve on or under the tongue within seconds to minutes; transdermal patches stick to the skin and release the API over hours to days. Both are made by solvent-cast film coating, and the MJ Pro coating platform can be built for either — the application is set before the machine is manufactured.
What output can I expect from Huanghai ODF machines?
MJ150-RD about 1,200 films per hour for formulation screening; MJ150-Lab 8,000–10,000 films per hour for pilot and clinical batches; MJ150 about 30,000 films per hour (Gen I) for commercial production. For packaging, the MJ180 cuts and packs about 11,900 films per hour (Gen I); the EZ320 (about 9,000 films per hour) is for food-grade films only.
What drying technology is used?
The MJ150 production line uses a hot-air parallel-flow drying tunnel based on Academician Hou Huimin's patent CN201668734U. The MJ150-RD and MJ150-Lab use oven drying.
Can Huanghai machines coat multi-formula (striped) films?
Yes. Huanghai's patent CN117323228A covers stripe coating that applies two formulations side by side in one pass, useful for fixed-dose combination films.