Multi-Formula Coating for ODFs: Tackling Combination Drug Challenges

Multi-Formula Coating for ODFs: Tackling Combination Drug Challenges

As Oral Dissolvable Films (ODFs) expand their role in both pharmaceuticals and functional supplements, multi-ingredient formulations have become a key development trend. Whether it’s drug combinations or synergistic nutrition (like vitamins and minerals), ensuring stable, uniform distribution of multiple actives on a single film presents a serious technical challenge.

Industry Pain Points

Traditional single-solution coating methods face the following limitations when formulating multi-ingredient ODFs:

  • Incompatible solubility leads to sedimentation or phase separation
  • Uneven API distribution affects dissolution curve consistency
  • Formulation ratios become unstable during scale-up
  • Cross-interactions between actives hinder quality and compliance

These issues severely limit the industrialization of combination ODFs. In pharma registration, poor dissolution consistency can directly lead to rejection.

HUANGHAI’s Multi-Formula Coating Solution

HUANGHAI has developed a patented stripe-style multi-formula coating process that enables precise zone-based coating on a shared substrate:

  • Independent Zones: Physically separate each formulation area to prevent cross-contamination
  • Micron-Level Precision: Achieved via blade-type coating, ensuring uniform thickness
  • Flexible Design: Supports dual, triple, or more component zones per film
  • GMP Compatibility: Enables consistent, repeatable results for registered drug products

This technology is ideal for formulation screening during pharmaceutical R&D, as well as functional food innovation at lab and pilot scale.

Patent Backing

This coating method is protected under Chinese patent CN117323228A, viewable on Google Patents.

Recommended Equipment

Conclusion

Combination ODFs are driven by real-world market needs, but demand robust technical execution. HUANGHAI’s multi-formula coating innovation provides a scalable, compliant solution from formulation to registration—making “multi-API, one film” a commercial reality.

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