Tablet Friability: Method Setup, Sample Size, and Intra-Batch Variability Control

Introduction: Friability looks simple, yet inconsistent variables and scattered records often add noise. By standardizing method settings and logbooks, results can be turned into actionable process signals.

Variables that are often overlooked

• Drum conditions & time; sample pre-treatment (de-dusting / edge trimming), cleaning, and weighing consistency.
• Insufficient or non-representative sample quantity, which magnifies random error.
• Fragmented records that prevent quick intra-/inter-batch trend analysis.

Method setup & recording recommendations

• Method card: Lock drum parameters, sample size, pre-treatment, and cleaning steps into a standardized template.
• Process control: Link friability to compression parameters and visual defects; maintain control charts to monitor trends.
• Exception retest: Define clear triggers and decision boundaries to reduce subjectivity.

HUANGHAI’s implementation checklist

• Provide standardized configurations and record templates for friability testing.
• Support a trend-analysis framework linked to other physico-chemical metrics (weight, hardness, thickness, etc.).

Conclusion

The value of friability lies in trend visibility. Once variables and records are unified, the data can genuinely guide tablet compression and tooling optimization.

Related products:

• Tablet Friability Instruments
• SY-6DN Multi-Purpose Tablet Tester