Building a Scalable ODF Manufacturing Line: A Guide to Pharmaceutical Film Production

Building a Scalable ODF Manufacturing Line: A Guide to Pharmaceutical Film Production

Building a Scalable ODF Manufacturing Line: A Guide to Pharmaceutical Film Production

Oral dissolving films (ODFs) have rapidly gained popularity in pharmaceutical and nutraceutical delivery due to their convenience, rapid onset of action, and patient-friendly format. Whether for pediatric, geriatric, or lifestyle medicine, ODFs represent the future of oral drug delivery.

To meet growing demand, pharmaceutical companies are adopting ODF manufacturing lines that can scale from pilot production to full commercial output—while ensuring regulatory compliance, operational efficiency, and consistent film quality.

What is ODF Manufacturing?

ODF (Oral Disintegrating Film) production involves several key steps:

  • Emulsification: Blending APIs and excipients into a uniform film-forming solution
  • Casting & Coating: Evenly applying the solution onto a substrate
  • Drying: Controlled evaporation to form a flexible, stable film
  • Cutting & Packaging: Precision cutting into individual doses and integration with packaging

Common Challenges in ODF Production

  • Maintaining consistent thickness and drug content uniformity
  • Preventing air bubbles, cracks, or delamination
  • Balancing drying speed with film integrity
  • Ensuring cutting accuracy and clean edges

HUANGHAI's ODF Manufacturing Solution

HUANGHAI offers modular, customizable equipment for every stage of ODF production, from R&D to commercial scale. Key components include:

  • Inline or batch emulsification tanks (optional)
  • Casting systems with adjustable coating width and thickness
  • Multistage drying tunnels with programmable temperature zones
  • Precision cutting and slitting units compatible with film-based formats
  • Flexible packaging solutions for strips or sachets

Why Choose HUANGHAI

  • Custom configurations for various drug loads, film dimensions, and packaging styles
  • Facility planning support including CAD layout design
  • In-house testing lab to evaluate formulation behavior and machine compatibility
  • GMP-compliant construction and full technical documentation
  • Installation, training, and global support available

Typical Applications

  • Prescription oral thin films (e.g., pain relief, allergy, CNS-targeted drugs)
  • Nutraceutical strips (e.g., vitamins, herbal actives)
  • Mucoadhesive or rapid-dissolving buccal films

Note: Specialized applications such as CNS-targeting or mucoadhesive films may require tailored equipment configuration and formulation validation.

Specialized Applications of ODF (Oral Dissolving Films)

Conclusion

ODFs are not just a trend—they're a strategic solution in modern drug delivery. HUANGHAI's ODF manufacturing systems are designed to grow with your needs, offering reliable, scalable, and compliant platforms that bring innovative formulations to market faster and more efficiently.

If you're planning to launch or expand your ODF production, our team of pharmaceutical engineers is ready to assist with technical consultation, line configuration, and scale-up support tailored to your goals.

Back to blog

Contact us