Vacuum Degassing and Multi-Channel Dissolution Testing
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In real laboratories, dissolution testing is rarely limited by the method alone. Two practical issues often stand in the way of reliable, efficient work: bubbles in the dissolution media and limited test throughput.
HUANGHAI addresses both challenges with a combination of the HTQ 1A vacuum degasser and multi-channel RCZ series dissolution testers, giving QC and R&D teams a more robust platform for day-to-day testing.
Why Degassing Matters in Dissolution Testing
Dissolved gases and bubbles in dissolution media are easy to overlook but can significantly disturb test results. Bubbles tend to:
- adhere to tablet or capsule surfaces and slow down wetting,
- stick to vessel walls near sampling zones, disturbing hydrodynamics,
- and cause irregularities in rotation and flow around the dosage form.
The result can be erratic dissolution profiles that are difficult to reproduce, especially for gas-sensitive formulations or low-solubility APIs.
HTQ 1A Vacuum Degasser: Removing Bubbles Before They Become a Problem
HUANGHAI’s HTQ 1A vacuum degasser is designed specifically for dissolution media preparation in solid-dosage testing. By applying controlled vacuum to the media before the test, it:
- removes dissolved gases and surface bubbles that would otherwise adhere to tablets or vessels,
- improves wetting behaviour and flow conditions around the dosage form,
- and enhances the reproducibility of dissolution results from run to run.
Because the unit is tailored to oral solid dosage workflows, operation is simple and fast – degassing can be integrated into routine media preparation without adding unnecessary complexity.
The Advantages of Multi-Channel Dissolution Testers
Accuracy is only half of the story. In busy QC labs, throughput also matters. HUANGHAI’s RCZ series dissolution testers are available in 1-, 6-, 8- and 12-vessel configurations to support different workloads:
- 1 or 6 vessels for method development, small-scale or special tests,
- 8 or 12 vessels for routine QC where many samples must be processed every day.
By choosing the appropriate configuration, a lab can match instrument capacity to its mix of R&D, pilot and commercial testing needs.
Real-Time Data Export and Integration
RCZ dissolution testers support real-time data display and export, making it easier to:
- capture dissolution profiles electronically,
- feed results into LIMS or local data-management tools,
- and align dissolution data with other physical tests in a unified logbook.
This reduces reliance on manual transcription, lowers the risk of recording errors and improves the traceability of dissolution results for audits and investigations.
Recommended Applications and Instrument Combinations
1. Pairing Dissolution with Physical Testing
Dissolution results become even more informative when evaluated together with basic physical tests. HUANGHAI recommends combining multi-channel dissolution testing with instruments such as the SY 6DN multi-purpose tablet tester, which can record hardness, thickness, diameter and disintegration in a single workflow.
By testing physical attributes on the same batch that undergoes dissolution testing, labs can:
- correlate dissolution behaviour with hardness, thickness and disintegration time,
- identify whether release problems are linked to compression, coating or formulation,
- and build a more complete picture of product performance.
2. Integrating Degassing and Dissolution into a Unified Logbook
The benefits of HTQ 1A and RCZ series instruments are maximised when their outputs are captured in a unified data platform. As outlined in HUANGHAI’s article on a unified tablet physical testing logbook , labs can record:
- degassing conditions and media preparation parameters,
- dissolution curves from multi-channel testers,
- and physical test results (weight, hardness, friability, disintegration) for the same batch.
This structure supports trend analysis, annual reviews and faster root-cause investigations when unusual results occur.
Putting It All Together: Accuracy and Efficiency in Dissolution Testing
Bubbles in the dissolution media and limited test throughput are practical obstacles that can undermine the value of dissolution testing – even when methods are well designed.
By using the HTQ 1A vacuum degasser to remove bubbles before the test, and combining this with multi-channel RCZ dissolution testers that offer real-time data export and flexible vessel counts, laboratories can:
- improve the accuracy and reproducibility of dissolution results,
- handle higher sample volumes without sacrificing data quality,
- and integrate dissolution data into a unified logbook alongside other critical tablet tests.
With a structured data-management approach, these tools help QC and R&D teams detect issues earlier and optimise product quality more efficiently.
Contact HUANGHAI to discuss how vacuum degassing and multi-channel dissolution testers can be configured for your laboratory’s needs.